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Evolution and diversification of the basal transcription machinery.

Trends Biochem. Sci.2015 Mar;40(3):127-9. Epub 2015 Feb 05
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摘要

Transcription initiation was once thought to be regulated primarily by sequence-specific transcription factors with the basal transcription machinery being largely invariant. Gradually it became apparent that the basal transcription machinery greatly diversified during evolution and new studies now demonstrate that diversification of the TATA-binding protein (TBP) family yielded specialized and largely independent transcription systems.

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