VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.

FEBS Lett.2015 Feb 27;589(5):576-80. Epub 2015 Jan 24

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We identified a yeast mutant with temperature-sensitive growth defects that were rescued by VCP expression. The mutation occurred in GPI10, which encodes a mannosyl transferase for glycosylphosphatidylinositol anchor formation in the endoplasmic reticulum, and caused a Gly469Glu substitution in Gpi10. The mutant exhibited increased unfolded protein response, which was partially rescued by VCP or Cdc48, and showed sensitivity against cell-wall stressors, which were not rescued by VCP. These results suggest a potential link between VCP/Cdc48 and Gpi10 functions in the control of cell growth.

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VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.

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