例如:"lncRNA", "apoptosis", "WRKY"

The mRNA decay factor PAT1 functions in a pathway including MAP kinase 4 and immune receptor SUMM2.

EMBO J.2015 Mar 4;34(5):593-608. Epub 2015 Jan 20
Milena Edna Roux 1 , Magnus Wohlfahrt Rasmussen 1 , Kristoffer Palma 2 , Signe Lolle 1 , Àngels Mateu Regué 1 , Gerit Bethke 3 , Jane Glazebrook 3 , Weiping Zhang 4 , Leslie Sieburth 4 , Martin R Larsen 5 , John Mundy 1 , Morten Petersen 6
Milena Edna Roux 1 , Magnus Wohlfahrt Rasmussen 1 , Kristoffer Palma 2 , Signe Lolle 1 , Àngels Mateu Regué 1 , Gerit Bethke 3 , Jane Glazebrook 3 , Weiping Zhang 4 , Leslie Sieburth 4 , Martin R Larsen 5 , John Mundy 1 , Morten Petersen 6
+ et al

[No authors listed]

Author information
  • 1 Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • 2 New England Biolabs Ltd, Whitby, ON, Canada.
  • 3 Department of Plant Biology, University of Minnesota, St. Paul, MN, USA.
  • 4 Department of Biology, University of Utah, Salt Lake City, UT, USA.
  • 5 University of Southern Denmark Institute for Biochemistry and Molecular Biology, Odense, Denmark.
  • 6 Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark shutko@bio.ku.dk.

摘要


Multi-layered defense responses are activated in plants upon recognition of invading pathogens. Transmembrane receptors recognize conserved pathogen-associated molecular patterns (PAMPs) and activate MAP kinase cascades, which regulate changes in gene expression to produce appropriate immune responses. For example, Arabidopsis MAP kinase 4 (MPK4) regulates the expression of a subset of defense genes via at least one WRKY transcription factor. We report here that MPK4 is found in complexes in vivo with PAT1, a component of the mRNA decapping machinery. PAT1 is also phosphorylated by MPK4 and, upon flagellin PAMP treatment, PAT1 accumulates and localizes to cytoplasmic processing (P) bodies which are sites for mRNA decay. Pat1 mutants exhibit dwarfism and de-repressed immunity dependent on the immune receptor SUMM2. Since mRNA decapping is a critical step in mRNA turnover, linking MPK4 to mRNA decay via PAT1 provides another mechanism by which MPK4 may rapidly instigate immune responses.

KEYWORDS: MAP kinases, decapping, immunity, mRNA decay, phosphorylation