Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.
Blood Cells Mol. Dis.2015 Apr;54(4):329-35. Epub 2014 Dec 20
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摘要
MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
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基因功能
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原始数据
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文献解读
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