Increased ARPP-19 expression is associated with hepatocellular carcinoma.
[No authors listed]
摘要
The cAMP-regulated phosphoprotein 19 plays a key role in cell mitotic G2/M transition. Expression of was increased in human hepatocellular carcinoma (HCC) compared to adjacent non-tumorous liver tissues in 36 paired liver samples, and the level of duanyu37P-19 in HCC tissues was positively correlated with the tumor size. To determine the interrelationship between duanyu37P-19 expression and HCC, we silenced duanyu37P-19 expression in the human hepatocarcinoma HepG2 and SMMC-7721 cells using lentivirus encoding duanyu37P-19 siRNA. HepG2 and SMMC-7721 cells with duanyu37P-19 knockdown displayed lowered cell growth rate, retarded colony formation and increased arrest at the G2/M phase transition. Silencing duanyu37P-19 in HCC cells resulted in decreased protein levels of phospho-(Ser) CDKs substrates and increased levels of inactivated cyclin division cycle 2 (Cdc2). Therefore, duanyu37P-19 may play a role in HCC pathogenesis through regulating cell proliferation.
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基因功能
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原始数据
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文献解读
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