例如:"lncRNA", "apoptosis", "WRKY"

Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system.

J. Bacteriol.2015 Mar;197(5):983-91. Epub 2014 Dec 22
Martha I Camacho 1 , Adrian F Alvarez 1 , Ricardo Gonzalez Chavez 1 , Tony Romeo 2 , Enrique Merino 3 , Dimitris Georgellis 4
Martha I Camacho 1 , Adrian F Alvarez 1 , Ricardo Gonzalez Chavez 1 , Tony Romeo 2 , Enrique Merino 3 , Dimitris Georgellis 4
+ et al

[No authors listed]

Author information
  • 1 Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México.
  • 2 Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
  • 3 Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
  • 4 Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México dimitris@ifc.unam.mx.

摘要


The hybrid sensor kinase BarA and its cognate response regulator UvrY, members of the two-component signal transduction family, activate transcription of CsrB and CsrC noncoding RNAs. These two small RNAs act by sequestering the RNA binding protein CsrA, which posttranscriptionally regulates translation and/or stability of its target mRNAs. Here, we provide evidence that CsrA positively affects, although indirectly, uvrY expression, at both the transcriptional and translational levels. We also demonstrate that CsrA is required for properly switching BarA from its phosphatase to its kinase activity. Thus, the existence of a feedback loop mechanism that involves the Csr and BarA/UvrY global regulatory systems is exposed.