例如:"lncRNA", "apoptosis", "WRKY"

zen and the art of phenotypic maintenance: canalization of embryonic dorsal-ventral patterning in Drosophila.

Fly (Austin). 2014;8(3):170-5. doi:10.4161/19336934.2014.983385
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摘要


We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this canalizing genetic circuitry and, consequently, have non-robust D/V patterning. In this review, we propose molecular mechanisms that may give rise to stereotyped BMP signaling, and we identify an additional species that could have decanalized D/V patterning. Extension of these analyses could in turn help explain why canalization is not a universal necessity for species survival.

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