Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.
Bull. Exp. Biol. Med.2014 Dec;158(2):192-6. doi:10.1007/s10517-014-2720-9. Epub 2014 Nov 29
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摘要
We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
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基因功能
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原始数据
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文献解读
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