The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish.
Chem. Commun. (Camb.). 2015;51(2):395-8. doi:10.1039/c4cc08075k. Epub 2014 Nov 18
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摘要
We report the development of a small fluorescent molecule, BDNCA3-D2, herein referred to as PT-Yellow. Soaking zebrafish embryos in PT-Yellow or intraperitoneal injection into adults results in non-toxic in vivo fluorescent labeling of the renal proximal tubules, the major site of blood filtrate reabsorption and a common target of injury in acute kidney injury. We demonstrate the applicability of this new compound as a rapid and simple readout for zebrafish kidney filtration and proximal tubule reabsorption function.
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基因功能
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原始数据
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文献解读
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