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Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia.

Hypertens Pregnancy. 2015 Feb;34(1):17-23. doi:10.3109/10641955.2014.951490. Epub 2014 Sep 02
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摘要


OBJECTIVES:To investigate into an association between circulating levels of vascular factors (VF: ACE, eNOS, PlGF and VEGF) and impaired fetal growth measured as a small for gestational age newborn (SGA) in women with gestational hypertension/preeclampsia. METHODS:A prospective observational trial in 46 patients in singleton pregnancies. Concentrations of VF were compared between participants who delivered SGA versus non-SGA newborns. RESULTS:only low levels of ACE were associated with significantly increased risk for SGA (for a cut-off value, LR: 1.4-3.6). CONCLUSIONS:Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia.

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