Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
J Biol Chem. 2014 Oct 10;289(41):28112-20. Epub 2014 Aug 26
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摘要
Metalloregulatory proteins allow cells to sense metal ions and appropriately adjust the expression of metal uptake, storage, and efflux pathways. Bacillus subtilis provides a model for the coordinate regulation of iron and manganese homeostasis that involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. Here, I review the structural and physiological bases of selective metal perception, the effects of non-cognate metals, and mechanisms that may serve to coordinate iron and manganese homeostasis.
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基因功能
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原始数据
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文献解读
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