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Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.

Nat Commun. 2014 Aug 19;5:4682
Kexin Chen 1 , Hongxia Ma 2 , Lian Li 1 , Rongyu Zang 3 , Cheng Wang 4 , Fengju Song 5 , Tingyan Shi 6 , Dianke Yu 7 , Ming Yang 8 , Wenqiong Xue 9 , Juncheng Dai 4 , Shuang Li 10 , Hong Zheng 5 , Chen Wu 7 , Ying Zhang 9 , Xiaohua Wu 11 , Dake Li 12 , Fengxia Xue 13 , Haixin Li 5 , Zhi Jiang 14 , Jibin Liu 15 , Yuexin Liu 16 , Pei Li 5 , Wen Tan 7 , Jing Han 4 , Jiang Jie 4 , Quan Hao 17 , Zhibin Hu 4 , Dongxin Lin 7 , Ding Ma 10 , Weihua Jia 9 , Hongbing Shen 4 , Qingyi Wei 18
Kexin Chen 1 , Hongxia Ma 2 , Lian Li 1 , Rongyu Zang 3 , Cheng Wang 4 , Fengju Song 5 , Tingyan Shi 6 , Dianke Yu 7 , Ming Yang 8 , Wenqiong Xue 9 , Juncheng Dai 4 , Shuang Li 10 , Hong Zheng 5 , Chen Wu 7 , Ying Zhang 9 , Xiaohua Wu 11 , Dake Li 12 , Fengxia Xue 13 , Haixin Li 5 , Zhi Jiang 14 , Jibin Liu 15 , Yuexin Liu 16 , Pei Li 5 , Wen Tan 7 , Jing Han 4 , Jiang Jie 4 , Quan Hao 17 , Zhibin Hu 4 , Dongxin Lin 7 , Ding Ma 10 , Weihua Jia 9 , Hongbing Shen 4 , Qingyi Wei 18
+ et al

[No authors listed]

Author information
  • 1 1] Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China [2].
  • 2 1] State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing 211166, China [2].
  • 3 1] Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2].
  • 4 State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • 5 Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
  • 6 1] Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • 7 Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
  • 8 College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
  • 9 State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.
  • 10 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • 11 Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • 12 Department of Gynecology, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
  • 13 Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • 14 Department of Gynecologic Surgery, Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 210009, China.
  • 15 Department of Tissue Bank, Nantong Tumor Hospital, Nantong, Jiangsu 226361, China.
  • 16 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • 17 Department of Urology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
  • 18 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2] Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.

摘要

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P(meta)<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.

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