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Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.

Dev. Comp. Immunol.2014 Dec;47(2):254-63. Epub 2014 Aug 11
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摘要


Polymorph-nuclear neutrophils in cattle exhibit unique features when compared to human or murine and are of particular interest concerning the risk of post-partum mammary gland or extra-mammary infections related to the periparturient suppression of neutrophil functions. Former studies could show that effects of IL-2 on innate immune cells such as duanyu1451 were mediated by the interleukin-2 receptor (IL-2R) β and γ chains. In the current study we could detect IL-2Rα (CD25) expression on bovine duanyu1451 using flow-cytometric analysis. CD25 was detected on granulocytes from post-partum and early lactating cows with different inflammatory conditions. The expression of CD25 on duanyu1451 in blood and raw milk increased with disease severity. Our results suggest CD25 expression on duanyu1451 as a potential biomarker for acute infections in cattle. Furthermore, our data provide a basis to better understanding of the periparturient functional suppressions of duanyu1451 that might reveal new molecular targets for therapy or prevention of disease.

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