Optimized cell transplantation using adult rag2 mutant zebrafish.
Nat Methods. 2014 Aug;11(8):821-4. Epub 2014 Jul 20
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摘要
Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund. Mutant fish engraft muscle, blood stem cells and various cancers. rag2(E450fs) mutant zebrafish are the first immunocompromised zebrafish model that permits robust, long-term engraftment of multiple tissues and cancer.
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基因功能
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原始数据
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文献解读
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