High-affinity IgE receptor gene polymorphism and allergic rhinitis in a Polish population.
[No authors listed]
摘要
INTRODUCTION:The high-affinity IgE receptor (FcÉRIβ subunit int 2) gene polymorphism is a candidate gene in atopic diseases and is associated with atopy. The aim of this biochemical study was to investigate the association of its intronic mutation and allergic rhinitis in a Polish population. MATERIALS AND METHODS:100 atopic patients and 85 controls were included in the study. Polymerase chain reaction-based analysis for FcÉRIβ subunit int 2 gene polymorphism was used for genotyping and detection. RESULTS:There was a difference in the frequencies of genotypes of FcÉRIβ subunit int 2 in allergic rhinitis patients and controls. The FcÉRIβ subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort. CONCLUSION:The results indicate that genetic factors may play an important role in the allergic rhinitis development in the investigated group.
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基因功能
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原始数据
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文献解读
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