Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.

ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and leading to cellular apoptosis, resulting from failed duanyu1670 detoxification. We identified that ZBTB3 plays an important role in the gene expression of duanyu1670 detoxification enzymes. Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the duanyu1670 detoxification system. Therefore, therapeutic strategies that target ZBTB3 could be used in selective cancer treatments.

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