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Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.

Front Behav Neurosci. 2014 Apr 22;8:133. doi:10.3389/fnbeh.2014.00133. eCollection 2014
Olga Lopatina 1 , Toru Yoshihara 2 , Tomoko Nishimura 3 , Jing Zhong 3 , Shirin Akther 3 , Azam A K M Fakhrul 3 , Mingkun Liang 3 , Chiharu Higashida 4 , Kohei Sumi 3 , Kazumi Furuhara 3 , Yuki Inahata 3 , Jian-Jung Huang 3 , Keita Koizumi 3 , Shigeru Yokoyama 3 , Takahiro Tsuji 3 , Yulia Petugina 5 , Andrei Sumarokov 6 , Alla B Salmina 5 , Koji Hashida 7 , Yasuko Kitao 7 , Osamu Hori 7 , Masahide Asano 8 , Yoji Kitamura 8 , Takashi Kozaka 8 , Kazuhiro Shiba 8 , Fangfang Zhong 9 , Min-Jue Xie 9 , Makoto Sato 10 , Katsuhiko Ishihara 11 , Haruhiro Higashida 1
Olga Lopatina 1 , Toru Yoshihara 2 , Tomoko Nishimura 3 , Jing Zhong 3 , Shirin Akther 3 , Azam A K M Fakhrul 3 , Mingkun Liang 3 , Chiharu Higashida 4 , Kohei Sumi 3 , Kazumi Furuhara 3 , Yuki Inahata 3 , Jian-Jung Huang 3 , Keita Koizumi 3 , Shigeru Yokoyama 3 , Takahiro Tsuji 3 , Yulia Petugina 5 , Andrei Sumarokov 6 , Alla B Salmina 5 , Koji Hashida 7 , Yasuko Kitao 7 , Osamu Hori 7 , Masahide Asano 8 , Yoji Kitamura 8 , Takashi Kozaka 8 , Kazuhiro Shiba 8 , Fangfang Zhong 9 , Min-Jue Xie 9 , Makoto Sato 10 , Katsuhiko Ishihara 11 , Haruhiro Higashida 1
+ et al

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Author information
  • 1 Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  • 2 Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
  • 3 Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
  • 4 Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan.
  • 5 Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  • 6 Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  • 7 Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences Kanazawa, Japan.
  • 8 Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
  • 9 Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan.
  • 10 Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan ; Research Center for Child Mental Development, University of Fukui Fukui, Japan.
  • 11 Department of Immunology and Molecular Genetics, Kawasaki Medical School Kurashiki, Japan.
全文

摘要

CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.

KEYWORDS: BST-1, emotion-related behavior, non-motor symptoms, oxytocin, social behavior

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