AROS has a context-dependent effect on SIRT1.
FEBS Lett.2014 May 2;588(9):1523-8. Epub 2014 Mar 26
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摘要
The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in cancer cells. We show that the interaction between the two proteins is weak and does not alter the activity of SIRT1 in non-cancerous human cells. The results of different in vitro SIRT1 activity assays disclosed as an inhibitor of SIRT1. The functional relationship between Aduanyu1670 and SIRT1 proved to be dependent on the biological context and experimental setting.
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基因功能
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原始数据
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文献解读
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