Expression of poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.

Poly(ADP-ribose) (PAR) turnover is required for many cellular processes, and highly relevant for cell death and survival. This post-translational protein modification is regulated by the synthesizing enzyme poly(ADP)ribose-polymerase and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). Previously, activity was found to be involved in photoreceptor degeneration in the rd1 mouse and in rd1-like conditions was the main Pduanyu37 family member contributing to photoreceptor cell death. Despite the manifest role of Pduanyu37 and PAR accumulation in photoreceptor cell death, the influence of PAR degradation on photoreceptor viability was still unknown. Here, we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.

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