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Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.

FEBS Lett.2014 May 2;588(9):1739-42. Epub 2014 Mar 19
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摘要


In this study, we revealed that GCN5 and early B cell factor 1 (EBF1) participate in regulation of protein kinase Cθ gene expression in an opposite manner in immature B cells. GCN5-deficiency in DT40 caused drastic down-regulation of transcription of In contrast, EBF1-deficiency brought about remarkable up-regulation of that of and re-expression of EBF1 dramatically suppressed transcription of duanyu1531θ. Chromatin immunoprecipitation assay revealed that GCN5 binds to the 5'-flanking region of the chicken gene and acetylates histone H3, and EBF1 binds to the 5'-flanking region of the gene surrounding putative EBF1 binding motifs.

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