PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis.
[No authors listed]
摘要
Esophageal squamous cell carcinomas (ESCCs) are highly invasive and have poor prognoses. We investigated the role of PTPLAD2, a protein tyrosine phosphatase-like A domain (PTPLAD) family member, in ESCC carcinogenesis. Survival analysis was performed using patient data. ESCC tissue samples lost PTPLAD2 heterozygosity and had decreased PTPLAD2 expression. Low PTPLAD2 expression and high correlated with poor prognosis. Overexpression of PTPLAD2 in ESCC cells reduced phosphorylation, decreased FoxM1, inhibited proliferation and decreased in mouse xenograft tumor formation. Therefore, PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces duanyu18133 phosphorylation. PTPLAD2 is a possible clinical target for ESCC treatment.
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基因功能
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原始数据
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文献解读
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