Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.

Biol. Pharm. Bull.2013;36(12):2009-11

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Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.

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Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.

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