Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.2013 Oct;69(Pt 10):1089-93. Epub 2013 Sep 28

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Succinyl-CoA:3-ketoacid CoA transferase (SCOT) plays a crucial role in ketone-body metabolism. SCOT from Drosophila melanogaster (DmSCOT) was purified and crystallized. The crystal structure of DmSCOT was determined at 2.64âÃ resolution and belonged to space group P212121, with unit-cell parameters a=76.638, b=101.921, c=122.457âÃ, Î±=Î²=Î³=90Â°. Sequence alignment and structural analysis identified DmSCOT as a class I CoA transferase. Compared with Acetobacter aceti succinyl-CoA:acetate CoA transferase, DmSCOT has a different substrate-binding pocket, which may explain the difference in their substrate specificities.

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Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster.

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