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LRRC45 is a centrosome linker component required for centrosome cohesion.

Cell Rep. 2013 Sep 26;4(6):1100-7. Epub 2013 Sep 12
Runsheng He 1 , Ning Huang , Yitian Bao , Haining Zhou , Junlin Teng , Jianguo Chen
Runsheng He 1 , Ning Huang , Yitian Bao , Haining Zhou , Junlin Teng , Jianguo Chen
+ et al

[No authors listed]

Author information
  • 1 Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and State, Key Laboratory of Bio-membrane and Membrane Bio-engineering, College of Life Sciences, Peking University, Beijing 100871, China.

摘要


During interphase, centrosomes are connected by a proteinaceous linker between the proximal ends of the centrioles, which is important for the centrosomes to function as a single microtubule-organizing center. However, the composition and regulation of centrosomal linker remain largely unknown. Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. Moreover, LRRC45 interacts with both C-Nap1 and rootletin and is phosphorylated by Nek2A at S661 during mitosis. After phosphorylation, both LRRC45 centrosomal localization and fiber-like structures are significantly reduced, which subsequently leads to centrosome separation. Thus, LRRC45 is a critical component of the proteinaceous linker between two centrioles and is required for centrosome cohesion.

基因