Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
[No authors listed]
摘要
Asrij/OCIAD1 is an endosomal protein expressed in stem cells and cardiovascular lineages and aberrantly expressed in several cancers. We show that dose-dependent modulation of cytokine-dependent signaling by Asrij regulates mouse embryonic stem cell pluripotency as well as Drosophila hematopoietic stem cell maintenance. Furthermore, mouse asrij can substitute for Drosophila asrij, indicating that they are true homologs. We identify a conserved region of Asrij that is necessary and sufficient for vesicular localization and function. We also show that Asrij and colocalize in endosomes and interact biochemically. We propose that Asrij provides an endosomal scaffold for duanyu18133 interaction and activation, and may similarly control other circuits that maintain stemness. Thus, Asrij provides a key point of control for spatial and kinetic regulation of stem cell signals.
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基因功能
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原始数据
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文献解读
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