Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

Nat Genet. 2013 Oct;45(10):1221-1225. doi:10.1038/ng.2733. Epub 2013 Aug 18

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摘要

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 Ã 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 Ã 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 Ã 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 Ã 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

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