Runx2 induces bone osteolysis by transcriptional suppression of TSSC1.
Biochem. Biophys. Res. Commun.2013 Sep 06;438(4):635-9. Epub 2013 Aug 08
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摘要
Advanced breast cancers frequently metastasize to bone, resulting in osteolytic lesions, however, the underlying mechanisms are poorly understood. Runx2, a bone-specific transcriptional factor, is abnormally expressed in highly metastatic breast cancer cells. Here, we found that TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. Furthermore, overexpression of Runx2 induces bone osteolysis in a TSSC1-dependent manner. Our results may provide a strategy for the treatment of breast cancer and the prevention of skeletal metastasis.
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基因功能
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原始数据
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文献解读
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