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Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.

Neuron. 2013 Aug 7;79(3):439-46
Gilberto J Soler-Llavina 1 , Pamela Arstikaitis , Wade Morishita , Mohiuddin Ahmad , Thomas C Südhof , Robert C Malenka
Gilberto J Soler-Llavina 1 , Pamela Arstikaitis , Wade Morishita , Mohiuddin Ahmad , Thomas C Südhof , Robert C Malenka
+ et al

[No authors listed]

Author information
  • 1 Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.

摘要


Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic cell adhesion molecules that trigger excitatory synapse assembly in cultured neurons and influence synaptic function in vivo, but their role in synaptic plasticity is unknown. shRNA-mediated knockdown (KD) of LRRTM1 and LRRTM2 in vivo in CA1 pyramidal neurons of newborn mice blocked long-term potentiation (LTP) in acute hippocampal slices. Molecular replacement experiments revealed that the LRRTM2 extracellular domain is sufficient for LTP, probably because it mediates binding to neurexins (Nrxs). Examination of surface expression of endogenous AMPA receptors (AMPARs) in cultured neurons suggests that LRRTMs maintain newly delivered AMPARs at synapses after LTP induction. LRRTMs are also required for LTP of mature synapses on adult CA1 pyramidal neurons, indicating that the block of LTP in neonatal synapses by LRRTM1 and LRRTM2 KD is not due to impairment of synapse maturation.