Role of nuclear localization of PSMB1 in transcriptional activation.
Biosci. Biotechnol. Biochem.2013;77(8):1785-7. Epub 2013 Aug 07
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摘要
The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.
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基因功能
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原始数据
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文献解读
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