例如:"lncRNA", "apoptosis", "WRKY"

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs.

Nat. Neurosci.2013 Sep;16(9):1266-74. Epub 2013 Jul 21
Dorota Studniarczyk 1 , Ian Coombs , Stuart G Cull-Candy , Mark Farrant
Dorota Studniarczyk 1 , Ian Coombs , Stuart G Cull-Candy , Mark Farrant

[No authors listed]

Author information
  • 1 Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

摘要


Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins such as stargazin (γ-2) modulate the properties of calcium-impermeable AMPARs (CI-AMPARs) and promote their synaptic targeting, the rules governing CP-AMPAR synaptic trafficking remain unclear. We used RNA interference to manipulate AMPAR-subunit and expression in γ-2-lacking stargazer cerebellar granule cells--the classic model of Tduanyu37 deficiency. We found that Tduanyu37 γ-7 selectively enhanced the synaptic expression of CP-AMPARs and suppressed CI-AMPARs, identifying a pivotal role of γ-7 in regulating the prevalence of CP-AMPARs. In the absence of associated both CP-AMPARs and CI-AMPARs were able to localize to synapses and mediate transmission, although their properties were altered. Our results also establish that synaptic receptors in granule cells require both γ-2 and γ-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice.