Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.
Genetics. 2013 Sep;195(1):289-91. Epub 2013 Jul 05
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摘要
We report that Cas9/gRNA mediates efficient genetic modifications in Drosophila. Through targeting seven loci, we achieved a germline efficiency of up to 100%. Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila.
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基因功能
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原始数据
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文献解读
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