The netrin G1 gene rs628117 polymorphism is associated with ischemic stroke.

Recent studies demonstrated that naturally occurring genetic alterations in synaptic plasticity-related genes may influence both stroke progression and poor functional recovery after stroke. Netrin G1 is an axonal protein involved in synaptic plasticity. In the present study, we evaluated the potential association of the netrin G1 gene rs628117 single nucleotide polymorphism with ischemic stroke in an Armenian population. In total, 127 patients with ischemic stroke and 128 healthy subjects (controls) were involved in this study. Genomic DNA samples of ischemic stroke patients and controls were genotyped for netrin G1 gene (NTNG1) rs628117 single nucleotide polymorphism using polymerase chain reaction with sequence-specific primers. Data were analyzed by Pearson's χ(2) test. The results obtained implicated rs628117 single nucleotide polymorphism of NTNG1 in pathogenesis of ischemic stroke. In particular, it was shown that the NTNG1 rs628117*G minor allele is positively associated with ischemic stroke and the carriers of this allele were overrepresented in ischemic stroke patients compared with controls. Our finding nominates the minor G allele of the NTNG1 rs628117 single nucleotide polymorphism as a risk factor for ischemic stroke at least in Armenian population.

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