TRIM39R, but not TRIM39B, regulates type I interferon response.
Biochem. Biophys. Res. Commun.2013 Jun 21;436(1):90-5. Epub 2013 May 23
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摘要
Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response.
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基因功能
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原始数据
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文献解读
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