TALEN-mediated editing of the mouse Y chromosome.
Nat. Biotechnol.2013 Jun;31(6):530-2. Epub 2013 May 12
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摘要
The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.
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基因功能
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原始数据
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文献解读
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