Human pentatricopeptide proteins: only a few and what do they do?

RNA Biol. 2013;10(9):1433-8. Epub 2013 Apr 23

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Pentatricopeptide repeat (PPR) proteins constitute a large family of RNA-binding proteins that contain a canonical 35 residue repeat motif. Originally identified in Arabidopsis thaliana, family members are found in protists, fungi, and metazoan but are by far most abundant in plant organelles. Seven examples have been identified in human mitochondria and roles have been tentatively ascribed to each. In this review, we briefly outline each of these PPR proteins and discuss the role each is believed to play in facilitating mitochondrial gene expression.

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Human pentatricopeptide proteins: only a few and what do they do?

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