DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.

Gene. 2013 Jul 25;524(2):373-6. Epub 2013 Apr 25

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Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan.

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DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.

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