The role of hnRPUL1 involved in DNA damage response is related to PARP1.

Heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) -also known as adenovirus early region 1B-associated proteins 5 (E1B-AP5) - plays a role in RNA metabolism. Recently, hnRPUL1 has also been shown to be involved in DNA damage response, but the function of hnRPUL1 in response to DNA damage remains unclear. Here, we have demonstrated that hnRPUL1 is associated with and recruited to DNA double-strand breaks (DSBs) sites in a poly (ADP-ribosyl) ation dependent manner. In turn, hnRPUL1 knockdown enhances the recruitment of Pduanyu371 to DSBs sites. Specifically, we showed that hnRPUL1 is also implicated in the transcriptional regulation of Pduanyu371 gene. Thus, we propose hnRPUL1 as a new component related to Pduanyu371 in DNA damage response and repair.

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