Identification of a histone acetyltransferase as a novel regulator of Drosophila intestinal stem cells.
FEBS Lett.2013 May 21;587(10):1489-95. Epub 2013 Mar 25
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摘要
One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator of Drosophila intestinal stem cells (ISCs). Expression of or a dominant negative allele of Atac2 generated more ISCs, while excessive Atac2 or a histone deacetylase inhibitor promoted ISC differentiation without affecting ISC survival or lineage specification. These findings extend our knowledge of epigenetic mechanisms in stem cell regulation.
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基因功能
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原始数据
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文献解读
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