Sex peptides and MIPs can activate the same G protein-coupled receptor.

Gen. Comp. Endocrinol.2013 Jul 1;188:137-43. Epub 2013 Feb 27

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In many animal species, copulation elicits a number of physiological and behavioral changes in the female partner. In Drosophila melanogaster, the main molecular effector of these physiological responses has been identified as sex peptide (SP). The sex peptide receptor (SPR) has been characterized and recently, its activation by Drosophila myoinhibiting peptides (MIPs)-in addition to SP-has been demonstrated. The myoinhibiting peptides are members of a conserved peptide family, also known as B-type allatostatins, which generally feature the C-terminal motif -WX6Wamide.

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Sex peptides and MIPs can activate the same G protein-coupled receptor.

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