[No authors listed]
Transit of proteins through the endosomal organelle following endocytosis is critical for regulating the homeostasis of cell-surface proteins and controlling signal transduction pathways. However, the mechanisms that control these membrane-transport processes are poorly understood. The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain. Here we present the crystal structure of the SNX17 FERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architecture of the atypical FERM domain and the molecular basis for recognition of these essential sorting sequences. We further show that the PX-FERM proteins share a promiscuous ability to bind a wide array of putative cargo molecules, including receptor tyrosine kinases, and propose a model for their coordinated molecular interactions with membrane, cargo, and regulatory proteins.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
Nt5dc3, Grm7, Olr1, Bcr, Nr3c2, Adgrv1, Adcyap1r1, Adrb2, Alk, App, Ddr1, Cr2, Cr1l, Egfr, Erbb2, Erbb3, Erbb4, Fgfr1, Flt1, Flt4, Lrp2, Gpr37, Hras, Igf1r, Il4ra, Insr, Itga3, Itgb1, Itgb2, Itgb3, Itgb5, Itgb6, Itgb7, Itln1, Itpr2, Itpr3, Ldlr, Lepr, Lrp1, Lrp8, Tlr7, Gpr37l1, Mttp, Notch1, Notch2, Notch3, Nppb, Npr1, Musk, Ntrk1, Ntrk2, Ntrk3, Pigr, Pla2r1, Ptpra, Ptprb, Ptprn2, Itgb4, Ret, Selp, Il23r, Tnfrsf1a, Trpc1, Tshr, Vipr1, Vldlr, Impg2, P2rx3, Gpr61, P2rx2, Gpr119, Amfr, Insrr, Gpr20, Gpr101, Trpv3, Ror1, Snx17, Fcrl5, Taok2, Gpr62, Gabrq, Cd200r1, Pex5l, Snx31, Loxl4, Rnmt, Gprc5c, Gpr160, Plxdc1, Tm7sf2, Slitrk5, Snx27, Gpr84, Gpr63, Tas1r2, Mcoln1, Lrp1b, ADCYAP1R1, GPR62, CD200R1, CR1L, CR2, GPR119, IL23R, ADRB2, TRPV3, EGFR, ERBB2, ERBB3, ERBB4, FGFR1, PLA2R1, P2RX2, FLT1, FLT4, ALK, SLITRK5, AMFR, GPR160, GPR20, GPR37, GRM7, HRAS, IGF1R, APP, IL4R, INSR, INSRR, ITGA3, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITPR2, ITPR3, LDLR, LEPR, LRP1, LRP2, NR3C2, MTTP, MUSK, NOTCH1, NOTCH2, NOTCH3, NPPB, NPR1, NTRK1, NTRK2, NTRK3, ROR1, OLR1, P2RX3, IMPG2, TLR7, PEX5L, NT5DC3, PIGR, LRP1B, GPR84, ITLN1, GABRQ, GPRC5C, PLXDC1, MCOLN1, PTPRA, PTPRB, PTPRN2, RET, BCR, SELP, TM7SF2, TNFRSF1A, TRPC1, TSHR, VIPR1, VLDLR, DDR1, LRP8, TAS1R2, GPR63, SNX27, FCRL5, GPR101, GPR61, ADGRV1, LOXL4, RNMT, GPR37L1, TAOK2, SNX17
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
{{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} |
{{ list.authorName }} {{ list.authorName }} |