[Effects of tripterine on NF-kappaB and eotaxin in nasal mucosa of allergic rhinitis rat].

OBJECTIVE:To investigate the relationship among the expressions of NF-kappaB, Eotaxin and the effects of tripterine in nasal mucosa of allergic rhinitis rat and to discuss the possible mechanism of tripterine on allergic rhinitis. METHOD:Forty healthy SD rats were randomly divided into four groups: OVA group,tripterine group (T group), DM group, and SC group. Allergic rhinitis model was established by OVA. The pathological changes were observed by HE staining. The expressions of NF-kappaB and Eotaxin were examined by SP immunohistochemical analysis. RESULT:There was no pathological change in SC group. Nasal mucosa in T and DM group was swelling,and there were some inflammatory cells. Nasal mucosa in OVA group was highly swelling, and there were abundant inflammatory cells. NF-kappaB and Eotaxin expression in OVA group was significantly different from the other three groups (P<0.01). And no difference was observed between T and DM groups (P>0.05). The expression of NF-kappaB in OVA group had positive correlation with the expression of Eotaxin (r=0.908, P<0.01). CONCLUSION:Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB.

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