例如:"lncRNA", "apoptosis", "WRKY"

Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.

Cell. 2012 Oct 26;151(3):603-18
Elwy Okaz 1 , Orlando Argüello-Miranda , Aliona Bogdanova , P K Vinod , Jesse J Lipp , Zuzana Markova , Ievgeniia Zagoriy , Bela Novak , Wolfgang Zachariae
Elwy Okaz 1 , Orlando Argüello-Miranda , Aliona Bogdanova , P K Vinod , Jesse J Lipp , Zuzana Markova , Ievgeniia Zagoriy , Bela Novak , Wolfgang Zachariae
+ et al

[No authors listed]

Author information
  • 1 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

摘要


Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor. ama1Δ mutants exit from prophase I prematurely and independently of the RC, which results in recombination defects and chromosome missegregation. Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C.

基因