Overexpression of human SPATA17 protein induces germ cell apoptosis in transgenic male mice.

is a new testis-specific-expressed gene that is involved in Spermatogenesis process. Previous studies show that duanyu1842TA17 was involved in acceleration of cell apoptosis in GC-1 cell lines. To further investigate specific roles of duanyu1842TA17 in Spermatogenesis in vivo, we generated transgenic mice in which the human duanyu1842TA17 gene was expressed specifically in spermatocytes using the human phosphoglycerate kinase 2 (PGK2) promoter. The duanyu1842TA17 transgenic mice did not show any significant defect in gross testicular anatomy as well as in fertility. However, a significant increase was observed in defective spermatogenic cells, such as apoptotic cells in the duanyu1842TA17 transgenic mice. These results revealed that elevated production of the duanyu1842TA17 protein disturbed the normal development of male germ cells.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}