例如:"lncRNA", "apoptosis", "WRKY"

G protein-coupled receptor deorphanizations.

Annu. Rev. Pharmacol. Toxicol.2013;53:127-46. doi:10.1146/annurev-pharmtox-010611-134548. Epub 2012 Sep 28
Olivier Civelli 1 , Rainer K Reinscheid , Yan Zhang , Zhiwei Wang , Robert Fredriksson , Helgi B Schiöth
Olivier Civelli 1 , Rainer K Reinscheid , Yan Zhang , Zhiwei Wang , Robert Fredriksson , Helgi B Schiöth
+ et al

[No authors listed]

Author information
  • 1 Department of Pharmacology, University of California, Irvine, Irvine, California 92617, USA. ocivelli@uci.edu

摘要


G protein-coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend. Most GPCRs are identified on the basis of their DNA sequences and thus are initially unmatched to known natural ligands. They are termed orphan GPCRs. Discovering their ligands-i.e., "deorphanizing" the GPCRs-gave birth to the field of reverse pharmacology. This review discusses the present status of GPCR deorphanization, presents a few examples of successes and surprises, and highlights difficulties encountered in these efforts.