KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.

is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between Kduanyu15353 variation and schizophrenia. To investigate a wider role of Kduanyu15353 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six Kduanyu15353 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that Kduanyu15353 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.

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