Mitochondria as sensors and regulators of calcium signalling.
Nat. Rev. Mol. Cell Biol.2012 Sep;13(9):566-78. Epub 2012 Aug 01
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摘要
During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention.
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文献解读
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