Insulin-like growth factors 1 and 2 regulate expression of Î²-casein in vitro in mouse mammary epithelial cells.

Bull. Exp. Biol. Med.2011 Dec;152(2):202-5. doi:10.1007/s10517-011-1488-4

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We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein Î²-casein in the presence of prolactin and hydrocortisone. It was found that Î²-casein expression is accompanied by cyclin D1 coexpression.

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Insulin-like growth factors 1 and 2 regulate expression of Î²-casein in vitro in mouse mammary epithelial cells.

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