Geroprotective effects of activation of D-GADD45 DNA reparation gene in Drosophila melanogaster nervous system.
Bull. Exp. Biol. Med.2012 Jan;152(3):340-3. doi:10.1007/s10517-012-1523-0
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摘要
The expression of D-GADD45 gene involved in DNA reparation in Drosophila melanogaster decreases with age. Overexpression of D-GADD45 in the drosophila nervous system prolongs the median and maximum life span without deterioration of the quality of life parameters (fertility and neuromuscular activity). The life span prolongation effect is due to more effective DNA reparation, as spontaneous level of DNA aberrations in the nerve tissue of larvae with D-GADD45 overexpression is reduced significantly.
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基因功能
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原始数据
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文献解读
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