Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
[No authors listed]
摘要
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 Ã 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 Ã 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 Ã 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
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基因功能
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原始数据
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文献解读
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