例如:"lncRNA", "apoptosis", "WRKY"

Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.

Aging Cell. 2012 Aug;11(4):717-21. doi:10.1111/j.1474-9726.2012.00831.x. Epub 2012 Jun 04
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摘要


Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.

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